01of 21Ellen Pompeo as Meredith GreyEllen Pompeo as Meredith Grey.ABCThe titular character ofGrey’s Anatomy, audiences were introduced to Meredith Grey on the morning of her first day as an intern at Seattle Grace hospital. On the first episode of the series, Meredith slept with Derek Shepherd, only to discover he was not just her co-worker but her superior.Meredith has been througha lotover the years. If you haven’t seen the show, it includes the deaths of her friends (and husband), a hospital shooting, plane crash, insurance fraud, etc. She’s also had a few love interests since McDreamy’s shocking death and is mom to three kids. Meredith is still on the show, but only after being fired for committing insurance fraud and doing community service.In September 2018,Ellen Pompeoexpressed her desire to leave the show, signaling thatit was a time for a “change.““My children are getting older, so I want to be more available to them now,” she toldEntertainment Weekly. “I can’t be an absentee mom if they’re teenagers; I have to be around to whip their butts. So it’s definitely time for change in my life. I’m really looking forward to it, and that’s the beauty of my situation. I have definitely played this out for everything that I possibly could.“She continued, “I’ve given it 200 percent of my energy and my love and my time and my commitment and my dedication. I still am fighting every day to make everything surrounding this show, the quality of the show, the storytelling; I’m still fighting for everything I can, for the quality to be good, for the actors to be happy, whether that’s well received or not. I still care very much about the show, and I think that it takes a lot of energy. So at some point I have to wrap it up.“But just one month later, in October 2018, Pompeo suggested she would bestaying on the seriesfor the foreseeable future.“And, you know, these numbers — there’s just no end in sight with streaming, and the show is so popular,” Pompeo toldEllen DeGeneres. “I gotta keep doing it, man, because we’re touching lives and making a difference.“However,her role was scaled back significantlyon season 19, with the Golden Globe-nominated actress appearing only on eight episodes, though she still continued to narrate most of the episodes. BeyondGrey’s Anatomy, Pompeo is set to star on and produce an upcoming Hulu limited series based on the 2009 filmOrphan.Pompeo has been married toChris Iverysince November 2007, and thecouple share three children.
01of 21
Ellen Pompeo as Meredith Grey
Ellen Pompeo as Meredith Grey.ABC

The titular character ofGrey’s Anatomy, audiences were introduced to Meredith Grey on the morning of her first day as an intern at Seattle Grace hospital. On the first episode of the series, Meredith slept with Derek Shepherd, only to discover he was not just her co-worker but her superior.
Meredith has been througha lotover the years. If you haven’t seen the show, it includes the deaths of her friends (and husband), a hospital shooting, plane crash, insurance fraud, etc. She’s also had a few love interests since McDreamy’s shocking death and is mom to three kids. Meredith is still on the show, but only after being fired for committing insurance fraud and doing community service.
In September 2018,Ellen Pompeoexpressed her desire to leave the show, signaling thatit was a time for a “change.”
“My children are getting older, so I want to be more available to them now,” she toldEntertainment Weekly. “I can’t be an absentee mom if they’re teenagers; I have to be around to whip their butts. So it’s definitely time for change in my life. I’m really looking forward to it, and that’s the beauty of my situation. I have definitely played this out for everything that I possibly could.”
She continued, “I’ve given it 200 percent of my energy and my love and my time and my commitment and my dedication. I still am fighting every day to make everything surrounding this show, the quality of the show, the storytelling; I’m still fighting for everything I can, for the quality to be good, for the actors to be happy, whether that’s well received or not. I still care very much about the show, and I think that it takes a lot of energy. So at some point I have to wrap it up.”
But just one month later, in October 2018, Pompeo suggested she would bestaying on the seriesfor the foreseeable future.
“And, you know, these numbers — there’s just no end in sight with streaming, and the show is so popular,” Pompeo toldEllen DeGeneres. “I gotta keep doing it, man, because we’re touching lives and making a difference.”
However,her role was scaled back significantlyon season 19, with the Golden Globe-nominated actress appearing only on eight episodes, though she still continued to narrate most of the episodes. BeyondGrey’s Anatomy, Pompeo is set to star on and produce an upcoming Hulu limited series based on the 2009 filmOrphan.
Pompeo has been married toChris Iverysince November 2007, and thecouple share three children.
02of 21James Pickens Jr. as Richard WebberJames Pickens Jr. as Dr. Richard Webber.ABCRichard Webber was introduced on the first episode of the series. As the former Chief of Surgery, Richard immediately recognized Meredith’s talent and lineage, having worked with her mother, Ellis Grey (Kate Burton).Not much has changed with Richard’s personality, but he has been through — like everyone else who’s been on the show — a lot. He lost his wife, was electrocuted, developed a dependency on alcohol and temporarily lost his job after helping Meredith commit insurance fraud.AlthoughJames Pickens Jr.has been a mainstay on the series and its spin-offs, he has also appeared onThe X-Files,Roseanne,YellowstoneandThe Connerswhile filmingGrey’s Anatomy.He married musician Gina Taylor in 1984. They have two children.
02of 21
James Pickens Jr. as Richard Webber
James Pickens Jr. as Dr. Richard Webber.ABC

Richard Webber was introduced on the first episode of the series. As the former Chief of Surgery, Richard immediately recognized Meredith’s talent and lineage, having worked with her mother, Ellis Grey (Kate Burton).
Not much has changed with Richard’s personality, but he has been through — like everyone else who’s been on the show — a lot. He lost his wife, was electrocuted, developed a dependency on alcohol and temporarily lost his job after helping Meredith commit insurance fraud.
AlthoughJames Pickens Jr.has been a mainstay on the series and its spin-offs, he has also appeared onThe X-Files,Roseanne,YellowstoneandThe Connerswhile filmingGrey’s Anatomy.
He married musician Gina Taylor in 1984. They have two children.
03of 21Chandra Wilson as Miranda BaileyChandra Wilson as Miranda Bailey.ABCMiranda Bailey was introduced to viewers as “The Nazi” for her stern demeanor and refusal to take any nonsense on the series premiere. Deep down, though, she loved and cared for her interns and worked hard to see them succeed.She still doesn’t take any crap from anyone as the Chief of Surgery. That’s not to say Miranda hasn’t had her own struggles, but throughout the years, she has been one of the more stable characters on the series.On season 15, she fired both Richard and Meredith after an insurance fraud incident, though they have since returned to work under her. Currently, she’s still attempting to keep everyone in line.During her long run onGrey’s Anatomy,Chandra Wilson, a four-time Emmy nominee, also appeared inA Single Woman(2008),Frankie & Alice(2010) andChristmas Harmony(2018), as well as aguest appearance onGeneral Hospitalin 2019.Wilson is the mother of three children.
03of 21
Chandra Wilson as Miranda Bailey
Chandra Wilson as Miranda Bailey.ABC

Miranda Bailey was introduced to viewers as “The Nazi” for her stern demeanor and refusal to take any nonsense on the series premiere. Deep down, though, she loved and cared for her interns and worked hard to see them succeed.
She still doesn’t take any crap from anyone as the Chief of Surgery. That’s not to say Miranda hasn’t had her own struggles, but throughout the years, she has been one of the more stable characters on the series.
On season 15, she fired both Richard and Meredith after an insurance fraud incident, though they have since returned to work under her. Currently, she’s still attempting to keep everyone in line.
During her long run onGrey’s Anatomy,Chandra Wilson, a four-time Emmy nominee, also appeared inA Single Woman(2008),Frankie & Alice(2010) andChristmas Harmony(2018), as well as aguest appearance onGeneral Hospitalin 2019.
Wilson is the mother of three children.
04of 21
Justin Chambers as Alex Karev
Justin Chambers as Alex Karev.ABC

Justin Chambersportrayed Alex Karev, the cocky, overconfident intern who had thenerveto call Meredith a nurse on the first episode.
After 15 years of redeeming his character flaws, Alex left his career, friendships and wife behind when he left Seattle Grace for Kansas to reunite with Izzie and gasp their twins she conceived using frozen embryos.
He added, “As I move on fromGrey’s Anatomy, I want to thank the ABC family,Shonda Rimes, original cast members Ellen Pompeo, Chandra Wilson and James Pickens, and the rest of the amazing cast and crew, both past and present, and, of course, the fans foran extraordinary ride.”
Since his exit, Chambers appeared on the Paramount+ seriesThe Offerin 2022 asMarlon Brando.
Chambers and his wife, Keisha, havefive children.
05of 21
Patrick Dempsey as Derek Shepherd
Patrick Dempsey as Derek Shepherd.ABC

Patrick Dempseytold PEOPLE, “I’m very grateful forGrey’s Anatomy.It’s given me the opportunity to do everything. But at the same time, there was a cost.”
The two-time Golden Globe nominee continued: “I think after a certain period of time, no matter how much money you make, you want control out of your own schedule.”
“It had been long enough. It was time for me to move on with other things and other interests,” Dempsey added of the decision. “I probably should have moved on a couple of years earlier. I stayed a bit longer than I should have.”
Fans have had a fewexciting moments during season 17, though, as McDreamy appeared on a handful of episodes.
06of 21Sara Ramírez as Callie TorresSara Ramirez as Callie Torres.ABCOur first glimpse of Callie Torres was as a badass surgical resident who fixed George O’Malley’s dislocated shoulder on season 2, episode 19.After 10 seasons on the series and a lot of drama between Torres and their ex-wife, Arizona Robbins, they finally agree that Torres should move to New York City to be happy.“I’m deeply grateful to have spent the last 10 years with my family atGrey’s Anatomyand ABC, but for now, I’m taking some welcome time off,“Sara Ramírezsaid in a statement. “Shonda’s been so incredible to work for, and we will definitely continue our conversations! I send my love to Ellen [Pompeo], the rest of the cast and crew, and I look forward to always being a part of the Shondaland family!“Since leavingGrey’s Anatomyin 2016, Ramírez joined the cast ofMadam Secretaryand later was cast as nonbinary podcast host Che Diaz inAnd Just Like That…In 2016, Ramírezcame out as bisexualand laternonbinaryin 2020. They married Ryan DeBolt in 2012, but in July 2021, Ramírezannounced their spliton Instagram.
06of 21
Sara Ramírez as Callie Torres
Sara Ramirez as Callie Torres.ABC

Our first glimpse of Callie Torres was as a badass surgical resident who fixed George O’Malley’s dislocated shoulder on season 2, episode 19.
After 10 seasons on the series and a lot of drama between Torres and their ex-wife, Arizona Robbins, they finally agree that Torres should move to New York City to be happy.
“I’m deeply grateful to have spent the last 10 years with my family atGrey’s Anatomyand ABC, but for now, I’m taking some welcome time off,“Sara Ramírezsaid in a statement. “Shonda’s been so incredible to work for, and we will definitely continue our conversations! I send my love to Ellen [Pompeo], the rest of the cast and crew, and I look forward to always being a part of the Shondaland family!”
Since leavingGrey’s Anatomyin 2016, Ramírez joined the cast ofMadam Secretaryand later was cast as nonbinary podcast host Che Diaz inAnd Just Like That…
In 2016, Ramírezcame out as bisexualand laternonbinaryin 2020. They married Ryan DeBolt in 2012, but in July 2021, Ramírezannounced their spliton Instagram.
07of 21
Sandra Oh as Cristina Yang
Sandra Oh as Cristina Yang.ABC

Cristina Yang was the headstrong, super-smart, no-nonsense intern who’d do just about anything to succeed. She also quickly became Meredith’s best friend.
Yang left Grey Sloan Memorial Hospital — this was after they renamed the hospital (again) — for the Klausman Institute for Medical Research in Switzerland. She has been mentioned on the show since, usually regarding phone calls, e-mails or letters.
When she left the show in 2014,Sandra OhtoldThe Hollywood Reporterthat she was open to returning when the series ends.
“I told [Shonda], “If you guys want to finish it out however you want to finish it out, I’d be more than happy to come back,” she said. “And if itdoesn’tfit in that way, I totally understand. I just want you to know that I’m available. Who knows! I might be doing something fabulous, and it might not work out, but I did say, ‘Yes, of course, I would.'”
08of 21
Eric Dane as Mark Sloan
Eric Dane as Mark Sloan.ABC

He seemingly survived the plane crash that killed his love interest, tricked us into thinking he would live when he had what the doctors called “The Surge” — a.k.a. one last burst of energy before dying — and then had to be pulled off of life support. It was another brutal blow.
Eric Danereportedlyleft the showafter being offered a role on TNT’sThe Last Ship, which he starred on for five seasons before the show ended in 2018.
“Grey’s Anatomyis a world — it’s not about any one individual actor, and the storylines were sort of … you know, heading in different directions,” Dane toldEntertainment Weeklyin 2013. “So it was an opportunity for me to go, and I was interested in something different. I loved doingGrey’s Anatomy. I would have done it until the final episode, but this was something I couldn’t pass up.”
Dane and actressRebecca Gayheartmarried in 2004, though Gayheartfiled for divorcein 2018. They sharetwo daughters,Billie BeatriceandGeorgia Geraldine.
09of 21
Chyler Leigh as Lexie Grey
Chyler Leigh as Lexie Grey.ABC

Bright-eyed and ready to save some lives, Lexie Grey started as an intern at Seattle Grace on season 3. She’s the half-sister of Meredith, which came as a shock to, well, everyone.
After finally finding love with Mark, Lexie’s death hit viewershard.She died in the plane crash that concluded season 8, leaving everyone (but especially Mark) heartbroken.
During season 17,she and Sloan returnedin yet anotherMeredith dream sequence.
In 2002, Leigh married her7th Heavencostar Nathan West. Thecouple share three children. The actress also opened up in 2019 aboutliving with bipolar disorderas part of the Be Vocal initiative.
10of 21
Katherine Heigl as Isobel “Izzie” Stevens
Katherine Heigl as Izzie Stevens.ABC

It was a rough ride for Izzie, who, on season 2, fell in love with a patient, Denny Duquette (Jeffrey Dean Morgan), who needed a heart transplant, risked her career to get him one and then had to cope with his death. She also developed brain cancer, which made her hallucinate that Denny was a ghost. Izzie had a few on-and-off relationships and eventually married Alex, but it was all short-lived when she was fired from Seattle Grace after the merger with Mercy West hospital on season 6. She made one last attempt to return to the hospital, but eventually, Alex told her to leave, ending her time on the series.
While viewers didn’t get to see her again, she was mentioned as the reason Alex left the hospital to be with her and their twins on season 16.
The real-life story behindKatherine Heigl’s departure is about as rocky.
It all started when Heigl withdrew her name from Emmy nominations in 2008, just one year after winning an Emmy for best supporting actress. The decision didn’t exactly keep her in good graces with the show’s creator and producers. She reportedly said at the time: “I did not feel that I was given the material this season to warrant an Emmy nomination, and in an effort to maintain the integrity of the academy organization, Iwithdrew my name from contention. In addition, I did not want to potentially take away an opportunity from an actress who was given such materials.”
In 2010, Rhimes toldOprah Winfreyof Heigl’s move, “On some level, it stung, and on some level, I was not surprised. When people show you who they are, believe them.”
Heigl told Howard Stern thatshe did apologize to Rhimes, saying, “I went in to Shonda and said, ‘I’m so sorry. That wasn’t cool, and I should not have said that.’ And I shouldn’t have said anything publicly. But at the time, I didn’t think anyone would notice … I just quietly didn’t submit, and then it became a story, and I felt I was obligated to make my statement, and … ‘Shut up, Katie.'”
In 2007, Heiglmarried musician Josh Kelley, with whom she shares three children —Naleigh, Adalaide and Joshua.
11of 21T. R. Knight as George O’MalleyT. R. Knight as George O’Malley.ABCAside from being the first intern to perform an appendectomy (and being dubbed “007” because he had a license to kill), George O’Malley was an overeager, kind-hearted intern who was totally in love with Meredith.Who could forget finding out that George was the badly injured, unrecognizable patient who saved a woman from an oncoming bus? It was one of the morebrutal character deaths onGrey’s.T.R. Knight, a 2007 Emmy nominee,left the showafter five seasons for a few reasons — citing lack of screen time, his character’s storyline and a “breakdown of communication” between himself and Rhimes toEntertainment Weeklyin 2009.“My five-year experience proved to me that I could not trust any answer that was given [about George],” he told the magazine.Hemade a surprise returnon a December 2020 episode.Since he departed the series, Knight has had several stints on shows such asThe Good Wife,11.22.63,The Catch,When We Rise,Genius: EinsteinandGenius: Picasso. He has also appeared on seasons 1 and 2 of HBO Max’sThe Flight Attendant.Knight has beenmarried to ballet dancerPatrick B. Leahy since 2013.
11of 21
T. R. Knight as George O’Malley
T. R. Knight as George O’Malley.ABC

Aside from being the first intern to perform an appendectomy (and being dubbed “007” because he had a license to kill), George O’Malley was an overeager, kind-hearted intern who was totally in love with Meredith.
Who could forget finding out that George was the badly injured, unrecognizable patient who saved a woman from an oncoming bus? It was one of the morebrutal character deaths onGrey’s.
T.R. Knight, a 2007 Emmy nominee,left the showafter five seasons for a few reasons — citing lack of screen time, his character’s storyline and a “breakdown of communication” between himself and Rhimes toEntertainment Weeklyin 2009.
“My five-year experience proved to me that I could not trust any answer that was given [about George],” he told the magazine.
Hemade a surprise returnon a December 2020 episode.
Since he departed the series, Knight has had several stints on shows such asThe Good Wife,11.22.63,The Catch,When We Rise,Genius: EinsteinandGenius: Picasso. He has also appeared on seasons 1 and 2 of HBO Max’sThe Flight Attendant.
Knight has beenmarried to ballet dancerPatrick B. Leahy since 2013.
12of 21Isaiah Washington as Preston BurkeIsaiah Washington as Preston Burke.ABCThe talented cardiothoracic surgeon was first introduced on the series premiere as, yes, extremely good-looking and brilliant, but he also made a mark as being tough on George to set an example for the other interns.On-screen, Burke left the series in 2007 after leaving Cristina at the altar. In reality,Isaiah Washingtonwas let go from the show because of an incident in which heallegedly used a homophobic slurabout castmate Knight. He did return for one episode on season 10 to urge Cristina to leave Washington and take over his hospital in Switzerland.Washington has continued to act after hisGrey’s Anatomyexit, most notably on The CW’sThe 100,Starz’sP-Valleyand in the 2022 filmCorsicana.He has been married to Jenisa Marie Garland since 1996, and they have three children together.
12of 21
Isaiah Washington as Preston Burke
Isaiah Washington as Preston Burke.ABC

The talented cardiothoracic surgeon was first introduced on the series premiere as, yes, extremely good-looking and brilliant, but he also made a mark as being tough on George to set an example for the other interns.
On-screen, Burke left the series in 2007 after leaving Cristina at the altar. In reality,Isaiah Washingtonwas let go from the show because of an incident in which heallegedly used a homophobic slurabout castmate Knight. He did return for one episode on season 10 to urge Cristina to leave Washington and take over his hospital in Switzerland.
Washington has continued to act after hisGrey’s Anatomyexit, most notably on The CW’sThe 100,Starz’sP-Valleyand in the 2022 filmCorsicana.
He has been married to Jenisa Marie Garland since 1996, and they have three children together.
13of 21Kate Walsh as Addison Montgomery ShepherdKate Walsh as Addison Montgomery Shepherd.ABCWhen we first met Addison Montgomery Shepherd, she showed up at Seattle Grace in an attempt to save her marriage to Derek. Shecheated on him with their friend, Mark, and wanted to make amends … just as Derek and Meredith were starting to get close.After losing out on a second chance with Derekandmissing out on getting a job at Seattle Grace, Addison cut her losses and left. On the bright side, she did get her own spin-off,Private Practice, which ran for six seasons.Like many of her colleagues,Kate Walshreturned to the serieson season 18 as a recurring character.Amid herGrey’s Anatomystints, Walsh appeared onFull CircleandFargoand had roles onBad Judge,13 Reason Why,The Umbrella Academy,Emily in ParisandSprung.In October 2022, Walsh revealed thatshe was engagedto Australian Andrew Nixon, whom she was first linked to in 2020.
13of 21
Kate Walsh as Addison Montgomery Shepherd
Kate Walsh as Addison Montgomery Shepherd.ABC

When we first met Addison Montgomery Shepherd, she showed up at Seattle Grace in an attempt to save her marriage to Derek. Shecheated on him with their friend, Mark, and wanted to make amends … just as Derek and Meredith were starting to get close.
After losing out on a second chance with Derekandmissing out on getting a job at Seattle Grace, Addison cut her losses and left. On the bright side, she did get her own spin-off,Private Practice, which ran for six seasons.
Like many of her colleagues,Kate Walshreturned to the serieson season 18 as a recurring character.
Amid herGrey’s Anatomystints, Walsh appeared onFull CircleandFargoand had roles onBad Judge,13 Reason Why,The Umbrella Academy,Emily in ParisandSprung.
In October 2022, Walsh revealed thatshe was engagedto Australian Andrew Nixon, whom she was first linked to in 2020.
14of 21
Kevin McKidd as Owen Hunt
Scott Garfield/ABC via Getty; Mitch Haaseth/ABC

SinceGrey’s Anatomy,Kevin McKiddhas appeared in several films, includingPercy Jackson & the Olympians: The Lightning Thief(2010),Home Sweet Hell(2015) andTulip Fever(2017). He voiced Lord MacGuffin inBrave(2012) and Reptillus Maximus in the ABC specialToy Story That Time Forgot(2014). In addition, McKidd has voiced the character Fenn Rau onStar Wars Rebels. McKidd has also worked behind the camera, directing more than 30 episodes ofGrey’s.
McKidd has four children. He shares two children, Iona and Joseph, with his ex-wife, Jane Parker. McKidd and Parkerfinalized their divorced in 2017after 17 years of marriage.
In 2018, hemarried Arielle Goldrath, with whom he shares sonAidenand daughterNava. Goldrathfiled for divorcein December 2022, just five months after McKiddannounced their spliton Instagram.
15of 21Jesse Williams as Jackson AveryBob D’Amico/Disney General Entertainment Content ; Kelsey McNeal/Disney General Entertainment ContentJackson Avery first joined the cast ofGrey’s Anatomyas a recurring character on season 6 before becoming a series regular on season 7. As the grandson of world-renowned surgeon Harper Avery (Chelcie Ross) and son of Catherine Avery (Debbie Allen), Jackson worked hard to make his own mark as a plastic surgeon while dating many of his fellow attendings — most notably, April Kepner. ThoughJesse Williamsdeparted after 12 seasonsin 2021, hereturned as a guest star for two episodesin 2022.Williams has appeared in several films since starring on the medical drama, includingThe Cabin in the Woods(2012),The Butler(2013),Snake and Mongoose(2013) andRandom Acts of Violence(2019). He also had a recurring role on season 3 ofStation 19. In 2022, Williams made his Broadway debut in the revival of the baseball playTake Me Out. He made headlines for his performance after he wasfilmed in the nude onstage, and the video circulated online.Williams marriedAryn Drake-Leein September 2012. They hada daughter, Sadie, and a son, Maceo, before separating in 2017. Theirdivorce was finalizedin 2020, and theysettled their custody disputein March 2022.
15of 21
Jesse Williams as Jackson Avery
Bob D’Amico/Disney General Entertainment Content ; Kelsey McNeal/Disney General Entertainment Content

Jackson Avery first joined the cast ofGrey’s Anatomyas a recurring character on season 6 before becoming a series regular on season 7. As the grandson of world-renowned surgeon Harper Avery (Chelcie Ross) and son of Catherine Avery (Debbie Allen), Jackson worked hard to make his own mark as a plastic surgeon while dating many of his fellow attendings — most notably, April Kepner. ThoughJesse Williamsdeparted after 12 seasonsin 2021, hereturned as a guest star for two episodesin 2022.
Williams has appeared in several films since starring on the medical drama, includingThe Cabin in the Woods(2012),The Butler(2013),Snake and Mongoose(2013) andRandom Acts of Violence(2019). He also had a recurring role on season 3 ofStation 19. In 2022, Williams made his Broadway debut in the revival of the baseball playTake Me Out. He made headlines for his performance after he wasfilmed in the nude onstage, and the video circulated online.
Williams marriedAryn Drake-Leein September 2012. They hada daughter, Sadie, and a son, Maceo, before separating in 2017. Theirdivorce was finalizedin 2020, and theysettled their custody disputein March 2022.
16of 21
Camilla Luddington as Jo Wilson
Danny Feld/ABC via Getty; ABC

Outside ofGrey’s Anatomy,Camilla Luddingtonis best known for voicing the popular character Lara Croft in theTomb Raidervideo game series. She also appeared inThe Pact II(2014) andThe Healer(2016).
Luddingtonmarried actor Matthew Allenin August 2019. They have two children, a daughter,Hayden, and a son,Lucas.
17of 21
Jessica Capshaw as Arizona Robbins
ABC (2)

Over a 10-season run onGrey’s Anatomy, Arizona Robbins became known for her fun-loving personality and roller-coaster relationship with Callie. The couple survived several fights, acustody battle, infidelity and an admission from Callie that she felt “suffocated” in their marriage. In the end, though, Arizona and Callie reconciled and moved to N.Y.C.
Capshaw has been married to businessman Christopher Gavigan since 2004. Theyshare four children.
18of 21
Sarah Drew as April Kepner
Bob D’Amico/Disney General Entertainment Content ; Eric McCandless/Disney General Entertainment Content

From the very beginning of her nine seasons onGrey’s Anatomy, the former attending trauma surgeon rubbed her co-workers the wrong way. However, April’s on-and-off relationship with Jackson was a highlight for many fans, changing the audience’s perception of her character.
Drew has been married to Peter Lanfer since 2002. They have two children: sonMicah Emmanueland daughterHannah Mali Rose.
19of 21Caterina Scorsone as Amelia ShepherdAdam Larkey/ABC via Getty; ABCAmelia Shepherd made her debut on season 3 of theGrey’s Anatomyspin-offPrivate Practice. The character later appeared as a guest star during seasons 7 and 8 ofGrey’s Anatomybefore joining the main cast on season 10 oncePrivate Practiceended. In the role of Derek’s youngest sister, Amelia struggled with her recovery from drug addiction and an on-and-relationship with Owen throughout seasons 11 and 12.In addition toPrivate Practice, Grey’s AnatomyandStation 19,Caterina Scorsoneappeared in the 2014 action filmThe November Man.Scorsone married musician Rob Giles in 2009, but they split in May 2020. They share three daughters:Eliza,Paloma “Pippa” MichaelaandArwen Lucinda. The actress has also become an advocate for parentsraising children with Down syndromeafter her daughter Pippa was born with the genetic disorder.
19of 21
Caterina Scorsone as Amelia Shepherd
Adam Larkey/ABC via Getty; ABC

Amelia Shepherd made her debut on season 3 of theGrey’s Anatomyspin-offPrivate Practice. The character later appeared as a guest star during seasons 7 and 8 ofGrey’s Anatomybefore joining the main cast on season 10 oncePrivate Practiceended. In the role of Derek’s youngest sister, Amelia struggled with her recovery from drug addiction and an on-and-relationship with Owen throughout seasons 11 and 12.
In addition toPrivate Practice, Grey’s AnatomyandStation 19,Caterina Scorsoneappeared in the 2014 action filmThe November Man.
Scorsone married musician Rob Giles in 2009, but they split in May 2020. They share three daughters:Eliza,Paloma “Pippa” MichaelaandArwen Lucinda. The actress has also become an advocate for parentsraising children with Down syndromeafter her daughter Pippa was born with the genetic disorder.
20of 21Kelly McCreary as Maggie PierceABC (2)Like otherGrey’scast members, Margaret Pierce made her first appearance on the series as a guest star. However, after it was revealed on the season 10 finale that she was the daughter of Richard and Ellis (making her Meredith’s half-sister), Margaret became a series regular. As a child prodigy who graduated medical school at 19, Margaret became the head of cardiothoracic surgery at 27.In addition to her role onGrey’s Anatomy,Kelly McCrearyhas also reprised her role as Margaret on ABC’sStation 19. She also voices Dot on the Netflix animated seriesHarvey Girls Forever!and appeared in the filmsLife(2015) and88(2022).McCrearymarried director Pete Chatmonin May 2019. Their first child, a daughter namedIndigo Wren, was born in October 2021. McCreary’s older sister, Crystal, also appeared onGrey’s Anatomyas Sabrina Webber (the niece of Richard) on the season 16 episode “Papa Don’t Preach.”
20of 21
Kelly McCreary as Maggie Pierce

Like otherGrey’scast members, Margaret Pierce made her first appearance on the series as a guest star. However, after it was revealed on the season 10 finale that she was the daughter of Richard and Ellis (making her Meredith’s half-sister), Margaret became a series regular. As a child prodigy who graduated medical school at 19, Margaret became the head of cardiothoracic surgery at 27.
In addition to her role onGrey’s Anatomy,Kelly McCrearyhas also reprised her role as Margaret on ABC’sStation 19. She also voices Dot on the Netflix animated seriesHarvey Girls Forever!and appeared in the filmsLife(2015) and88(2022).
McCrearymarried director Pete Chatmonin May 2019. Their first child, a daughter namedIndigo Wren, was born in October 2021. McCreary’s older sister, Crystal, also appeared onGrey’s Anatomyas Sabrina Webber (the niece of Richard) on the season 16 episode “Papa Don’t Preach.”
21of 21
Kim Raver as Teddy Altman
Randy Holmes/Disney General Entertainment Content ; ABC

Upon leavingGrey’s Anatomyin 2012,Kim Raverhad a recurring role on the NBC sci-fi seriesRevolutionand starred on24: Live Another DayandFull Circle. Since returning toGrey’s Anatomyon season 19, she has also appeared onAPB,Ray DonovanandDesignated Survivor.
In July 2000, Raver married French filmmaker Manu Boyer, and they share two sons:Luke WestandLeo Kipling.
source: people.com